Overview Join Amgen as a Rare Disease Biology Scientist to advance our portfolio of therapies for rare diseases. You will be a core member of multidisciplinary teams, using experimental and data-driven approaches to uncover disease mechanisms and identify therapeutic targets. You'll work at the intersection of autoimmune biology, tissue remodeling, and human data, contributing to mechanistic insights and portfolio decisions. This role offers collaborative, scientifically rigorous work with opportunities to translate findings into meaningful patient impact.
Compensation / Benefits- comprehensive employee benefits package
- retirement and savings plan with company contributions
- stock-based long-term incentives
- discretionary annual bonus or incentive plan
- award-winning time-off plans
- flexible work models where possible
Responsibilities- Design, execute, and analyze in vitro and ex vivo studies to probe disease mechanisms and test therapeutic hypotheses
- Generate high-quality data to support target identification, validation, and program progression in rare disease research
- Investigate Thyroid Eye Disease related biology including immune dysregulation and tissue remodeling
- Integrate experimental results with literature, human genetics, and clinical data to develop mechanistic insights
- Apply computational and data analysis tools to evaluate datasets and aid target prioritization
- Develop and implement innovative experimental approaches to improve rigor and translational relevance
- Collaborate across disease biologists, computational scientists, translational researchers, and partner functions
- Present findings to project teams and governance forums; contribute to knowledge-sharing and documentation
- Build relationships with internal and external collaborators including academic partners and experts
- Contribute to scientific discussions, target reviews, and portfolio evaluations
- Embrace a culture of scientific curiosity, collaboration, and continuous learning
Key requirements- PhD in Immunology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline OR
- Master's degree with 2 years of scientific research experience OR
- Bachelor's degree with 4 years of scientific research experience
- Excellent communication skills
- Teamwork and collaboration in matrixed environments
- Ability to balance scientific rigor with urgency and adaptability
- Design and execution of cell-based, molecular, and biochemical assays
- Experience with primary human cells, fibroblast systems, tissue-derived cultures, organoid models or advanced in vitro disease models
- Understanding of tissue remodeling, fibrosis, extracellular matrix biology
