Scientist-II

In this temporary Scientist role, you will support protein expression and purification for screening and structural studies within the Discovery Sciences team. You will work with E. coli, baculovirus/insect, and mammalian expression systems, including cell culture and scale-up, to produce proteins for high-throughput screening and crystallography. You will establish or follow purification protocols (IMAC, SEC, and other media) and contribute to experimental design, data analysis, and project collaboration. Located in Spring House, PA, you'll thrive in a fast-paced, team-driven environment and help advance structure-based discovery efforts.

• Protein expression across multiple systems (E. coli, baculovirus/insect, mammalian) including small-scale evaluation and large-scale culture
• Establish or follow purification protocols (IMAC, SEC, other media) to supply proteins for HTS and crystallography
• Design experiments, analyze data, troubleshoot, and maintain detailed records
• Collaborate with cross-functional teams and communicate effectively to support projects

• BS or MS in biological sciences, biochemistry, or related discipline
• 3-5 years laboratory experience (preferably 2 years in industry)
• Experience in protein expression and purification; familiarity with AKTA purification systems is a plus
• Excellent interpersonal, organizational, verbal and written communication skills
• Ability to work in a fast-paced, team-oriented environment and coordinate with multiple functional groups

• team-oriented
• strong communication
• problem-solving
• protein expression in E. coli, baculovirus/insect, and mammalian systems
• protein purification (IMAC, SEC)
• AKTA purification systems