Overview As a Scientist at FL106, you will design and execute preclinical studies to advance therapeutic programs. You will lead flow cytometry, primary cell isolation, and imaging work to characterize cell and tissue phenotypes and validate targets. Your work will span in vitro and in vivo mouse studies, with a focus on mechanistic insights using siRNA and advanced assays. You will collaborate across teams to drive project goals and mentor junior scientists in a fast-paced, collaborative environment. This role provides an opportunity to contribute to transformative drug delivery research at a well-supported biotech company.
Compensation / Benefits- healthcare coverage
- annual incentive program
- retirement benefits
- broad range of other benefits
Responsibilities- Design, execute, and analyze complex in vitro and in vivo experiments to support research programs
- Lead multi-parameter flow cytometry assays including panel design, optimization, and data interpretation
- Perform and optimize primary cell isolation from tissues (enzymatic/mechanical dissociation, MACS, FACS) while preserving viability and native signatures
- Conduct microscopy-based assays (high-content imaging, immunofluorescence, confocal, intravital imaging) to characterize phenotypes and target engagement
- Support mouse studies (disease models, dosing, tissue collection, phenotypic analysis)
- Develop and apply siRNA-based approaches for target validation and mechanistic studies
- Analyze data, generate reports, and present findings to cross-functional teams
- Collaborate with internal and external stakeholders to advance project goals
- Mentor junior scientists and foster a collaborative team environment
- Maintain accurate records and ensure compliance with institutional and regulatory guidelines
Key requirements- Ph.D. in Molecular Biology, Cell Biology, or related field with 3-6+ years of experience (industry preferred), or M.S. with significant experience
- Strong expertise in flow cytometry including cell sorting, panel design, troubleshooting, and data analysis (FlowJo or similar)
- Hands-on experience with primary cell isolation from mouse tissue (dissociation, MACS, isolation of rare/fragile populations)
- Experience with microscopy techniques and image analysis software (ImageJ/Fiji, Imaris)
- Demonstrated experience with siRNA design, delivery, and functional validation
- Strong data analysis and problem-solving skills
- Excellent communication and presentation skills
- Ability to work independently and collaboratively in a fast-paced environment
- Strong communication
- Collaborative mindset
- Problem-solving orientation
- Flow cytometry (FACS)
- Panel design and data analysis (FlowJo)
- Primary cell isolation from mouse tissue (MACS, enzymatic/mechanical dissociation)
