Overview In this role you will drive the development and optimization of IHC and tissue-based workflows to support oncology products and clinical assay development. You will work within the Oncology Product Development team to translate R&D methods into robust clinical workflows, tackling staining optimization, artifact investigation, and assay validation. You'll collaborate cross-functionally to enable smooth transfer to clinical operations and contribute to projects that shape diagnostic capabilities. This position offers exposure to automated platforms, advanced histology, and molecular biology techniques in a fast-paced environment.
Compensation / Benefits- comprehensive medical, dental, vision plans
- life and disability benefits
- fertility care benefits and free testing for employees and immediate family
- pregnancy and baby bonding leave
- 401k benefits
- commuter benefits
Responsibilities- Design and execute development, verification, and validation studies for IHC, histology, and tissue-based workflows
- Develop and optimize IHC assays including antibody selection, titration, antigen retrieval, staining conditions, and controls
- Evaluate pre-analytical variables (tissue fixation, FFPE processing, embedding, sectioning, H&E, slide prep)
- Troubleshoot workflows on automated IHC/ISH platforms and investigate staining artifacts and assay variability
- Plan and conduct moderate- to high-complexity experiments and analyze data with Excel, JMP, and image-analysis tools
- Collaborate with Pathology, Clinical Laboratory Ops, Quality, Automation, and cross-functional teams to transfer methods to clinical workflows
- Author study protocols, validation reports, SOPs, and transfer documentation; provide training during implementation
- Communicate progress, findings, risks, and recommendations to project teams and stakeholders
Key requirements- Ph.D. in related field with 2 years industry experience or Master's with 5 years or Bachelor's with 6-8+ years industry experience
- Strong hands-on expertise in IHC assay development, optimization, and troubleshooting
- Knowledge of FFPE tissue workflows and histology; antigen retrieval, antibody titration, controls
- Experience with automated IHC/ISH platforms; Roche BenchMark ULTRA IHC/ISH System is a strong plus
- Experience with H&E staining, microtomy, microscopy, digital pathology or image analysis
- NGS and molecular biology experience is a plus (FFPE nucleic acid extraction, PCR/qPCR, library prep, hybrid capture)
- Experience in regulated clinical laboratory or LDT environment preferred
- Ability to design/execute experiments independently and interpret data
- Strong technical writing, communication, collaboration, and organizational skills
- strong communication
- collaboration
- problem-solving
- IHC assay development
- antibody characterization/titration
- antigen retrieval
