Overview As a member of Lilly Medicine Foundry, you support the transfer and readiness of peptide downstream processes for early-phase cGMP manufacturing. You will work within the Process Translation and Execution (PTE) team to translate development knowledge into scalable clinical supply, collaborating across functions to optimize purification and downstream steps. You'll engage in tech transfers, process improvements, and data-driven decision making to enable rapid startup and steady-state operations. This role offers meaningful impact by accelerating novel manufacturing capabilities in a groundbreaking facility.
Compensation / Benefits- comprehensive compensation and bonus potential
- 401(k) plan
- pension benefits
- medical, dental, vision coverage
- flexible benefits program
- well-being programs
Responsibilities- Evaluate and facilitate transfer of peptide downstream processes from development labs to pilot plant operations
- Perform peptide purification and isolation, assess purification methods
- Execute peptide downstream procedures (reverse-phase chromatography, TFF, lyophilization, precipitation & drying)
- Evaluate safety of incoming procedures with safety group and process engineering
- Order and stage chemicals; obtain reference materials; set up analytical methods
- Reprocess and analyze analytical data to support fact-based decisions
- Familiarize plant readiness for process steps including reactions, purification, TFF, lyophilization, precipitation & drying
- Conduct use-tests of in-process materials and document definitive lab trials for plant readiness
- Maintain detailed lab notebooks and prepare technical packages for tech transfers
- Author/review technical documents (tech transfer plans, SOPs, batch records)
- Apply scientific knowledge to identify process improvements and implement new technologies
- Support RCA and CAPAs; assist in deviations, quality events, and investigations
- Collaborate to drive cross-functional root cause analysis and corrective actions
Key requirements- B.S. or M.S. in chemistry, chemical engineering, or related field
- 3+ years of peptide synthesis purification and/or manufacturing experience with peptide API
- Reverse-phase chromatography experience preferred
- Authorized to work in the United States on a full-time basis
- Experience with batch records, tech transfer, and scale-up processes
- Familiarity with analytical techniques (HPLC/UPLC, LC-MS, GC, NMR) and data analysis
- high motivation and rapid learning
- strong attention to detail
- excellent written and verbal communication
- peptide purification and downstream manufacturing
- reverse-phase chromatography
- TFF (tangential flow filtration)
