Overview In this role, you will lead Kymera's PBPK/PBBM capability to predict human PK and oral bioavailability across species and support first-in-human dose selection. You will shape workflows, standards, and software strategy, collaborating cross-functionally to translate preclinical data into actionable clinical guidance. You will develop mechanistic dissolution and IVIVC models to link product performance to in vivo behavior and contribute to regulatory submissions. This position offers high impact by advancing degrader programs and ensuring scientifically rigorous, data-driven decision making.
Compensation / Benefits- competitive base salary
- annual bonus eligibility
- equity participation
- comprehensive benefits
Responsibilities- Define and scale PBPK/PBBM workflows, standards, and software strategy for the organization
- Apply translational PBPK/PBBM to predict human PK and oral bioavailability and inform first-in-human dose selection
- Collaborate with CMC to support formulation selection and optimization via PBBM
- Develop IVIVC and mechanistic dissolution models to connect in vitro and in vivo performance and support regulatory specifications
- Address clinical pharmacology questions (DDI, food effects, special populations) using PBPK to guide study design and dose adjustments
- Embed in multidisciplinary project teams to provide real-time study design and rapid model iteration
- Coordinate with CROs and collaboration partners to generate data and analyses
- Represent DMPK perspective on project teams and prepare regulatory-submission-ready reports
Key requirements- PhD or PharmD (or equivalent) in pharmaceutical sciences, DMPK, pharmacokinetics, or related fields
- 7+ years of hands-on PBPK/PBBM experience
- Deep understanding of ADME/DMPK and biopharmaceutics
- Significant hands-on GastroPlus experience (required) and ability to manage modeling work independently
- Proven ability to build mechanistic absorption and whole-body PBPK models and translate preclinical data to human PK
- Experience modeling oral molecules with developability challenges and beyond-rule-of-five modalities (preferred)
- Proficiency in scripting (R, Python, or MATLAB) for data handling and QC
- Simcyp modeling experience (preferred)
- Track record of PBPK/PBBM contributions to regulatory submissions (IND, NDA, DDI) (preferred)
- DMPK project representative experience (preferred)
- Excellent cross-functional collaboration and clear communication with stakeholders (required)
- collaboration
- clear communication
- adaptability
- PBPK/PBBM
- ADME/DMPK
- GastroPlus
