Overview In this role, you will lead translational and mechanistic investigations in sepsis and septic ARDS, leveraging human biospecimens and single-cell approaches within a multidisciplinary team. You translate molecular findings into testable hypotheses and potential therapeutic targets, collaborating with bioinformatics and biostatistics experts. The position offers opportunities to shape publications, grants, and cross-disciplinary projects in a premier clinical research environment. This is a chance to drive biomedical discovery from patient samples toward precision medicine at Mayo Clinic Jacksonville.
Compensation / Benefits- Medical plan options
- Delta Dental or reimbursement for dental
- Vision plan with national network
- Pre-Tax savings (HSA/FSAs)
- Competitive retirement package
Responsibilities- Lead mechanistic and translational studies in sepsis and septic ARDS
- Work with primary human cells and biospecimens from well-characterized critically ill patients
- Apply single-cell and molecular approaches to identify disease-associated cells and pathways
- Translate transcriptomic and molecular findings into testable mechanistic hypotheses
- Use molecular and pharmacologic approaches to define pathway function and evaluate potential therapeutic targets
- Collaborate with bioinformatics and biostatistics investigators to integrate laboratory, molecular, and clinical data
- Lead and contribute to manuscripts, scientific presentations, and grant applications
- Collaborate with faculty and trainees on research in shock, resuscitation, critical illness, and other areas of acute care
Key requirements- PhD, MD/PhD, MD, or equivalent in a relevant biomedical discipline
- Must reside within the United States
- Strong wet-lab experience including cell culture and molecular/protein assays
- Experience with primary human cells, clinical biospecimens, and/or single-cell biology
- Experience designing rigorous mechanistic experiments with appropriate controls and pathway validation
- Interest or experience in therapeutics, pharmacology, drug discovery, or target validation
- Relevant experience in sepsis, immunology, inflammation, vascular/endothelial biology, acute lung injury/ARDS, or oxidative/redox biology (desirable)
- Basic proficiency in statistical analysis
- Strong scientific communication, collaboration, and writing skills
- Strong scientific communication
- Collaboration
- Effective writing
- Molecular biology and cellular wet-lab techniques
- Cell culture
- Molecular/protein assays
