Overview As Analytical Development Scientist, you will lead physicochemical characterization of development candidates, including peptides and PROTACs, to support lead selection and CMC work. You will drive solid-state analytics, salt/polymorph screening, and method development for Drug Substance and Drug Product, working with cross-functional teams to enable progression from Discovery to first-in-human studies. You will mentor juniors and contribute to regulatory filings. This role sits at the intersection of science, development strategy, and quality in a collaborative, values-led environment.
Responsibilities- Design, plan, and execute studies to define properties of development candidates
- Lead solid-state screening activities including salt and polymorphs
- Develop analytical methods for Drug Substance and Drug Product
- Collaborate with Discovery, Drug Safety, DMPK, Process Chemistry, Formulation, and Late Phase Analytical Development
- Provide technical leadership within projects and mentor junior staff
- Address project issues with integrated, cross-functional solutions
- Author technical reports and contribute to regulatory filings
Key requirements- 8+ years in industry with Bachelor's degree in related fields
- 6+ years with Master's degree in related fields
- PhD in a relevant discipline with no minimum industry experience
- Strong understanding of polymorphism and solid-state screening
- Expertise in solid-state analytical techniques and equipment (X-ray powder diffraction, DSC, TGA, DVS, microscopy, spectroscopy)
- Strong analytical method development (HPLC, GC, Karl Fischer, dissolution)
- GMP laboratory experience and practical troubleshooting skills
- Cross-functional collaboration and strong scientific writing skills
- Experience with external vendors and internal resource coordination
- Knowledge of peptides and PROTACs; familiarity with in silico tools preferred
- cross-functional collaboration
- technical communication
- mentorship
- polymorphism and solid-state analytics
- HPLC/GC/Karl Fischer/dissolution testing
- X-ray powder diffraction, DSC, TGA, DVS
