Overview In this Scientist role, you will investigate molecular drivers of cancer cell identity and therapy response within the Tumor Intrinsic Biology group. You'll apply protein and nucleic acid biochemistry to study transcriptional regulation and macromolecular complexes, collaborating across oncology biology, chemistry, structural biology, translational medicine, and computational sciences. Your work aims to reveal mechanistic insights and advance early discovery programs. This position offers a meaningful opportunity to shape cancer biology research within a mission-driven company.
Compensation / Benefits- discretionary annual bonus
- discretionary stock-based long-term incentives
- paid time off
- benefits package including medical, dental, vision, life insurance
Responsibilities- Design and execute experiments to probe protein and nucleic acid complexes in transcriptional regulation and cancer biology
- Develop biochemical, biophysical, and cellular methods to characterize protein interactions and multi-subunit complexes
- Generate mechanistic insights to support target identification, validation, and mechanism-of-action studies in early discovery oncology
- Collaborate with multidisciplinary teams across oncology biology, chemistry, structural biology, translational medicine, and computational sciences
- Communicate findings through presentations, reports, and team discussions while staying current with advances in cancer biology and RNA biology
Key requirements- Bachelor's degree with 5+ years experience OR Master's with 3+ years OR PhD with 0+ years
- Strong background in protein-nucleic acid biochemistry, biophysics, molecular biology
- Experience reconstituting and characterizing endogenous multi-subunit protein and ribonucleoprotein complexes (preferably from human cells)
- Experience with biochemical/biophysical approaches to macromolecular interactions; familiarity with SPR, BLI, fluorescence polarization, ITC, EMSA desirable
- Knowledge of transcriptional regulation, lineage determinants, RNA biology, chromatin regulation, or cancer signaling; experience studying cancer-relevant transcriptional programs is highly desirable
- Ability to work independently and in cross-functional teams with effective communication and problem-solving skills
- collaborative
- problem-solving
- effective communication
- protein-nucleic acid biochemistry
- biophysics
- molecular biology
