Overview As Principal Scientist, you will lead early clinical development for infectious disease programs, shaping translational medicine strategies from preclinical to early human trials. You will collaborate with discovery scientists and late-stage clinical researchers to validate targets and accelerate development. You'll drive biomarker and clinical pharmacology plans to support Proof-of-Concept and regulatory filings, while fostering cross-functional partnerships. This role offers the chance to shape translational pipelines in a collaborative, impact-driven environment with global reach.
Compensation / Benefits- medical, dental, vision
- retirement benefits, including 401(k)
- paid holidays and vacation
- compassionate and sick days
- annual bonus and long-term incentive
- hybrid work arrangement
Responsibilities- Provide clinical perspective for target identification/validation and design translational experiments to justify development
- Lead early development strategy from preclinical to Phase 2/3, including safety, PK/PD, and PoC demonstrations
- Develop and execute biomarker strategies across First-in-Human to PoC, including experimental medicine studies
- Lead clinical pharmacology studies across all phases and support regulatory filings with documentation
- Design and execute studies to validate clinical biomarkers (blood/tissue sampling, imaging, wearable devices, behavioral readouts)
- Collaborate with cross-functional teams (discovery, pharmacology, toxicology, statistics, regulatory affairs, global trials)
- Engage with internal/external scientific communities, including thought leaders and conference activities
- Work with global research sites and external partners to advance development programs
Key requirements- MD or MD/PhD
- strong background in basic and/or clinical translational research
- experience in early clinical development and translational medicine
- familiarity with infectious disease therapeutic areas and cross-functional collaboration
- leadership
- collaboration
- excellent scientific communication
- Clinical Research
- Early Clinical Development
- Infectious Disease
