Overview In this role you will lead integrated translational and clinical biomarker strategies across oncology and hematology programs, guiding decisions from early development through late-stage trials. You'll translate biology into testable hypotheses and ensure biomarker plans inform go/no-go decisions and dose/regimen choices. You will collaborate across discovery, clinical development, regulatory, and data science to deliver high-value evidence that shapes program direction. This is a strategic, cross-functional leadership role focused on rigorous, scalable biomarker science with meaningful impact.
Compensation / Benefits- annual bonus
- long-term incentive
- comprehensive benefits package
- health, dental, vision insurance
- retirement benefits (401(k
- paid holidays, vacation, and sick days
Responsibilities- Develop and lead integrated biomarker strategies across oncology and hematology programs with cross-functional teams
- Translate disease biology and mechanism into translational hypotheses and fit-for-purpose biomarker approaches
- Define how biomarkers inform development questions including proof of biology, target engagement, dose selection, patient selection, response assessment, and resistance
- Ensure strategies are focused, scalable, and linked to actions and outcomes
- Serve as biomarker representative on cross-functional program teams and provide strategic input
- Collaborate with Discovery, Clinical Development, Quantitative Sciences, Regulatory, Data Science, Clinical Operations, Pathology, Diagnostics, and other functions
- Lead interpretation of biomarker and clinical datasets and translate findings into actionable recommendations
- Characterize disease heterogeneity, molecular drivers, treatment response, resistance mechanisms, and biological determinants of outcomes
- Develop and evaluate patient-selection and precision-medicine strategies across genomic, transcriptomic, proteomic, and other biomarkers
- Apply circulating and tissue-based biomarker approaches (ctDNA, MRD, profiling, immunophenotyping, PD biomarkers) as appropriate
- For hematologic malignancies, incorporate molecular response, MRD, clonal evolution, mutational burden, lineage/phenotype, and resistance alterations
- For solid tumors, address target expression, tumor biology, molecular subtype, immune contexture, circulating biomarkers, and predictive markers
- Evaluate emerging biomarker technologies and analytical approaches for development impact
- Contribute to biomarker strategies supporting companion diagnostics or regulatory biomarker development
- Communicate biomarker strategies, results, risks, and recommendations clearly to stakeholders
- Provide scientific guidance and mentorship to biomarker scientists and foster collaboration
- Support publications, scientific presentations, and external collaborations
Key requirements- Significant experience developing and executing translational or clinical biomarker strategies in oncology or hematology drug development
- Strong scientific expertise in cancer biology, hematologic malignancies, translational oncology, or related discipline
- Demonstrated ability to translate hypotheses into biomarker strategies that inform clinical development decisions
- Solid understanding of mechanism of action, disease biology, heterogeneity, pharmacology, biomarkers, endpoints, and development strategy
- Experience with biomarker modalities such as NGS, ctDNA, MRD, immunohistochemistry, flow cytometry, gene-expression profiling, proteomics, or similar
- Ability to lead cross-functional work in a matrixed environment and influence without direct authority
- Strong analytical and problem-solving skills to synthesize complex data into decision-oriented conclusions
- Ability to prioritize high-value biomarker work to enable decisions
- Excellent written and verbal communication skills for stakeholder engagement
- Working knowledge of biostatistics, bioinformatics, quantitative sciences, and multidimensional biomarker data analysis
- Strategic mindset focused on scientific rigor, prioritization, scalability, and actionable evidence
- Strategic thinking
- Collaborative leadership
- Clear scientific communication
- Biomarker strategy development
- Translational medicine
- NGS / ctDNA / MRD
