S
Not Specified Permanent

Boston, Massachusetts · USA job

Principal Scientist, Machine Learning - Multimodal Biological Reasoning

Seres Therapeutics

Boston, Massachusetts

Job description

Overview

In this role you will lead the development of polyintelligent AI systems that fuse human biology expertise with machine intelligence to enable multi-modal, multi-scale reasoning for biology. You will guide architecture, data exploration, benchmarking, and integration of reasoning engines into the AI Scientist platform to advance autonomous scientific workflows. You will identify high-value use cases across Flagship and portfolio companies and translate biological needs into technical plans. You will work with cross-functional teams to translate discoveries into real-world biological solutions at scale. This is an opportunity to shape a new capability that could transform venture creation and

Compensation / Benefits
  • healthcare coverage
  • annual incentive program
  • retirement benefits
  • broad range of other benefits
Responsibilities
  • Own the roadmap from architecture through model readiness, benchmarking, and integration
  • Guide multi-modal, multi-scale model design with a biological lens for mechanism-of-action, target discovery, perturbation biology, pathways, protein function, and autonomous workflows
  • Translate biology into model requirements and evaluation criteria for real scientific workflows
  • Build and integrate reasoning engines into the AI Scientist platform for autonomous science
  • Source and shape portfolio use cases by engaging with Flagship teams and end-users to define success criteria and data assets
  • Communicate strategic direction and scientific results to internal stakeholders and public forums
Key requirements
  • Industry-leading expertise in modern LLMs, multimodal modeling, representation learning, fine-tuning, post-training, benchmarking, and ML systems
  • Deep experience in computational biology, AI-for-biology, AI-enabled drug discovery, translational data science, biological foundation models, or scientific discovery platforms
  • Ability to scope high-value use cases with scientists, define success criteria, and translate needs into technical execution plans
  • Working knowledge of genomic, transcriptomic, perturbation, protein sequence/structure, pathways, imaging, pathology, or time-series biological data
  • Strong judgment on mechanism-of-action reasoning, target discovery, perturbation biology, interpretability, and validation
  • Experience leading small technical teams through ambiguous problems
  • Clear communication with ML researchers, data engineers, scientists, executives, and venture leaders
  • Comfort in an entrepreneurial environment aiming to create new capabilities for company creation and scientific discovery
  • strong communication
  • leadership and team mentorship
  • cross-functional collaboration
  • LLMs
  • multimodal modeling
  • representation learning

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