Overview As Principal Scientist in DMPK at Alnylam, you will lead the design and execution of DMPK strategies to advance oligonucleotide therapeutics from discovery through clinical development. You will collaborate with R&D teams to optimize tissue delivery and translational pharmacology, and integrate PK/PD, efficacy, safety, and biomarkers to guide program decisions. You will represent DMPK in cross-functional governance, contribute to regulatory submissions, and mentor junior scientists while scaling DMPK capabilities. This role offers high-impact opportunities to shape translational science at a leader in RNAi therapeutics.
Compensation / Benefits- medical, dental, and vision coverage
- life and disability insurance
- 401(k) with generous company match
- paid time off, wellness days, holidays
- two company-wide recharge breaks
- family resources and leave
Responsibilities- Develop and implement DMPK strategies to support discovery, candidate selection, translational research, and clinical development of oligonucleotide therapeutics and other drug modalities
- Design, execute, interpret, and communicate DMPK studies to characterize ADME, PK/PD relationships, and translational pharmacology
- Collaborate with Research scientists to optimize tissue delivery, pharmacology, and candidate selection for advancement into development
- Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership to integrate PK/PD data, efficacy, safety, and biomarkers for development decisions
- Apply quantitative approaches, including modeling and simulation, to support dose prediction and development strategy
- Represent DMPK on multidisciplinary project teams and in governance discussions
- Lead or contribute to DMPK reports, regulatory submission content, and responses supporting CTA, IND, NDA filings
- Provide scientific mentorship and build DMPK capabilities across the organization
- Manage multiple programs, deliverables, and priorities in a fast-paced environment while maintaining high-quality output
- Present findings and recommendations to project teams, senior management, external collaborators, and regulatory agencies
Key requirements- Ph.D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biomedical engineering, or a related scientific discipline
- Minimum 6+ years of industry experience in pharmaceutical or biotechnology drug discovery and development
- Strong understanding of ADME, PK/PD principles, and translational pharmacology
- Experience developing and executing DMPK strategies for discovery- and/or development-stage programs
- Direct experience contributing to CTA and/or IND filings, including preparation or review of regulatory submission content
- Proven ability to work effectively in highly matrixed, multidisciplinary teams
- Strong quantitative, analytical, and problem-solving skills, with ability to integrate diverse datasets to drive decisions
- Excellent written, verbal, presentation, and interpersonal communication skills
- Demonstrated ability to multitask, manage multiple projects, meet timelines, and adapt to changing priorities
- cross-functional collaboration
- effective communication
- mentorship
- ADME
- PK/PD
- translational pharmacology
