Overview As a Senior Research Scientist in Computational Genomics at Vertex, you will apply human genetics and genomics to drive target discovery and therapeutic development. You will work with cross-functional teams to design and interpret multi-omic and genomic studies that inform strategy, biomarker development, and mechanism. You will translate complex data into actionable recommendations, leveraging AI and ML to accelerate discovery. This role offers impact across discovery programs in lung diseases and pain, within a collaborative, innovation-driven culture.
Compensation / Benefits- annual bonus and equity awards
- medical, dental, and vision benefits
- paid time off including summer and winter shutdown
- educational assistance including student loan repayment
- commuting subsidy
- 401(k)
Responsibilities- Collaborate with cross-functional project teams to define scientific questions addressable by genetics and genomics
- Design, execute, and interpret human genetic, genomic, and multi-omic studies to advance target discovery and biomarker development
- Apply computational and statistical methods to integrate internal and public data for actionable insights
- Own analyses from question through recommendations and clearly communicate conclusions and next steps
- Shape genomics strategies across discovery programs ensuring rigorous study design and alignment with project goals
- Partner with computational and experimental scientists to leverage AI/ML approaches in genomics
- Contribute to scientific publications, internal reports, and regulatory submissions
Key requirements- Strong background in human genetics and genomics with disease biology applications
- Ability to translate complex datasets into actionable conclusions and recommendations
- Proven track record of driving questions from study design to impact on projects
- Excellent communication to diverse audiences
- Interest in applying ML/AI to biological discovery
- Collaborative, team-oriented mindset with willingness to mentor others
- clear communication
- team collaboration
- growth mindset
- R
- Python
- Unix/Linux
