Overview You will contribute to the CRISPR-X team, advancing in vivo gene insertion across tissues. You work closely with cross-disciplinary groups to push editing and delivery toward clinical readiness. You apply immunology expertise to develop novel editing modalities and robust data analyses. This role offers impact in shaping next-generation gene therapies and expanding cutting-edge in vivo approaches.
Compensation / Benefits- base pay plus bonus
- equity
- benefits package
- onsite work environment
- full-time employment
- competitive compensation range (Scientist II)
Responsibilities- Design and execute workflows for gene editing in primary cells, including T cells
- Conduct molecular biology work with advanced cloning and diverse delivery strategies (transfection, viral transduction, tLNP)
- Collaborate across CRISPR Therapeutics and with external partners to drive projects toward clinical readiness
- Evaluate editing efficiency, cell phenotype, and construct expression; ideate new strategies
- Perform ddPCR assays to quantify transgene integration; design and run T cell phenotyping by flow cytometry
- Leverage immunology background to drive innovative editing, delivery, and expression approaches
- Analyze data across experiments and present to broad audiences
- Manage and curate critical data with statistical analysis and troubleshooting
Key requirements- Extensive experience with gene editing and synthetic immunology in academic or industry settings
- PhD with 2-5+ years (or non-PhD with 10-12+ years) of relevant experience
- Strong cloning, flow cytometry, primary T cell culture, editing assays, and T cell phenotype/function assessment skills
- Experience managing multiple projects and collaborating across teams
- Strong communicator; collaborative team player
- Adaptable and detail-oriented
- Problem-solving with a sense of urgency
- Molecular cloning
- Flow cytometry
- Primary T cell culture
