Overview In this role you will support imaging components of clinical trials as part of the Imaging Core Laboratory, focusing on radio-theranostic agents. You will drive dosimetry and quantitative image analysis to ensure protocol compliance and patient safety. You'll collaborate with sponsors, QA teams, and cross-functional colleagues to advance radiopharmaceutical trials. The position offers a concrete impact on trial quality and radiophysics workflows within a global CRO. You join a mission-driven environment that values scientific rigor and hands-on problem solving.
Compensation / Benefits- medical, dental, vision
- 401(k)
- vacation policy
- paid holidays
- work from home flexibility
- disability insurance
Responsibilities- Advise on radiation dosimetry and nuclear imaging for sponsor-proposed clinical trial protocols
- Design imaging and dosimetry measures for diagnostic or therapeutic radionuclides
- Perform QA checks on nuclear imaging and dosimetry data to meet protocol requirements
- Calibrate scanners via phantom scans and dosimetry factor calculations
- Perform image reconstruction and analysis (PET/CT, SPECT/CT, planar imaging)
- Compute dosimetry (e.g., %ID/g, biological half-life, TIAC, dose) in normal and tumor tissues using software
- Ensure compliance with MIRC and ICRP radiation safety guidelines
- Compile project-specific status reports and timelines for imaging components of trials
- Execute project tasks following GCP, 21CFR Part 11, SOPs, and trial protocols
Key requirements- PhD or Master in physics or related field with at least 5 years' experience in dosimetry for internal radiotherapy (PRRT)
- Or PhD in physics or related field with at least 2 years' experience in dosimetry for PRRT
- Expertise in quantitative image reconstruction (nuclear medicine)
- Expertise in internal radiotherapy and dosimetry calculation using MIRD S-values, 3D-RD and/or OLINDA/EXM 1.0
- Experience with internal radiation dosimetry for gamma, positron and alpha emitters (preferred)
- Experience in clinical trials or pharmaceutical environment (preferred)
- Communication with sponsors and cross-functional teams
- Attention to detail and quality mindset
- Problem-solving and analytical thinking
- Quantitative image reconstruction (nuclear medicine)
- Dosimetry calculation methods and software (MIRD S-values, 3D-RD, OLINDA/EXM 1.0)
- Nuclear imaging modalities (PET/CT, SPECT/CT)
