N
Not Specified Permanent

Boston, Massachusetts · USA job

Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory

Novartis

Boston, Massachusetts

Job description

Overview

In this role you lead a biomarker assay development lab to enable translational decisions across discovery to clinical development. You will guide a high-performing team and collaborate with translational medicine, data science, and cross-functional partners to shape biomarker strategies. You'll work across renal, liver, fibrosis, and emerging diseases to accelerate patient-focused breakthroughs. This position offers strategic leadership, scientific impact, and opportunities to access emerging technologies in a collaborative, innovative culture.

Compensation / Benefits
  • flexible and hybrid working options
  • minimum 14 weeks paid parental leave
  • insurance plans
  • retirement plans
  • wellbeing resources
  • global recognition programs
Responsibilities
  • Lead development and qualification of biomarker assays for discovery, translational research, and clinical development
  • Design fit-for-purpose assay strategies for target engagement, pharmacodynamics, and patient stratification
  • Drive lab operations, resource planning, and prioritization to meet portfolio goals
  • Build and mentor a high-performing biomarker science team
  • Foster excellence, accountability, and continuous improvement across the lab
  • Partner with Translational Medicine, Data Science, and cross-functional teams on biomarker strategies
  • Establish and manage external collaborations to access new technologies
  • Oversee outsourced assay activities to ensure high-quality translational data
  • Provide scientific leadership informing translational plans and clinical development strategies
  • Represent the lab in cross-functional forums and contribute to program decisions
Key requirements
  • PhD, MD, or equivalent in a life sciences discipline
  • Extensive experience developing biomarker assays in pharma/biotech
  • Deep expertise across cellular, circulating, proteomic, genetic, and genomic biomarker approaches
  • Proven success designing, qualifying, and implementing assays for preclinical and clinical studies
  • Strong experience with PCR, next-generation sequencing, immunoassays, and mass spectrometry
  • Demonstrated ability to lead, develop, and inspire teams within complex matrix organizations
  • Experience managing external partners and CROs to deliver outcomes
  • Excellent collaboration, scientific communication, and stakeholder engagement skills
  • collaboration
  • stakeholder engagement
  • mentorship
  • biomarker assay development
  • PCR
  • next-generation sequencing

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