Overview In this role you will support discovery and development by designing, executing, and interpreting in vitro ADME assays while expanding lab automation for high-quality data. You will collaborate with cross-functional PK teams to guide compound optimization and decision-making, contributing to novel methodologies and automated end-to-end workflows. The position combines hands-on ADME work with AI-enabled analytics to scale throughput and standardize assay operations, within a mission-driven biotech context.
Compensation / Benefits- comprehensive benefits package
- 401(k) with company contribution and match
- performance-based cash incentive
- eligibility for annual equity awards
- generous time off package
Responsibilities- Plan, execute and report ADME assays (metabolic stability, permeability) to support PK strategies
- Interpret in vitro ADME data to inform early discovery and optimization decisions
- Contribute to new ADME methodologies and expand assay capabilities
- Advance automation strategies (liquid handling, miniaturization, multiplexing) to increase capacity and reduce manual work
- Execute and contribute to automated end-to-end ADME workflows with AI-enabled analytics
- Develop methods for bio-analysis using LCMS-MS, HRMS, and ICP-MS
- Troubleshoot lab instrumentation and automation platforms
- Manage study timelines, objectives and budgets and track progress
- Communicate data, strategy and results to project teams
- Contribute to internal ADME reports and regulatory documents (IND, IMPD, NDA)
- Participate in cross-departmental teams and initiatives
- Complete organizational trainings and adhere to SOPs, quality, and HSE guidelines
Key requirements- BSc or MSc with relevant ADME/DMPK experience
- BSc: 7+ years; MSc: 4+ years in ADME/DMPK
- Experience in drug discovery or development laboratory or CRO/Pharma/Biotech desirable
- Experience in metabolic stability and permeability assays; cell culture experience a plus
- Experience with automation integrated with AI-enabled analytics is highly desirable
- Knowledge of related disciplines (bioanalytical, toxicology, biomarkers) in drug discovery
- Ability to work in a cross-functional, dynamic team; strong organizational and problem-solving skills
- Fluent oral and written English
- collaboration
- critical thinking
- strong communication
- ADME/DMPK
- metabolic stability assays
- permeability assays
