C
Not Specified Permanent

Philadelphia, Pennsylvania · USA job

Associate Principal Scientist, Preclinical Research

Cabaletta Bio

Philadelphia, Pennsylvania

Job description

Overview

In this role you drive discovery research as a molecular biology and gene-delivery expert, leading a team to develop assays and reagents for preclinical programs. You collaborate across Discovery Research and other departments to establish a product pipeline and support IND-enabling studies. You oversee experimental planning, resources, and data interpretation to advance the CAR-T platform for autoimmune diseases. You contribute to process improvements and adopt new technologies, shaping rapid, data-driven progress.

Compensation / Benefits
  • competitive benefits
  • PTO
  • stock option plans
Responsibilities
  • Lead a team executing R&D experiments, assay development, and reagent production
  • Collaborate with scientists to design and run critical experiments for new preclinical projects
  • Plan and interpret team lab work within program timelines
  • Identify required resources (people, equipment, space) to meet objectives
  • Coordinate with cross-functional peers and management to set objectives, report results, and align on goals
  • Drive process improvements and introduce new molecular biology and gene delivery technologies
Key requirements
  • PhD in Molecular Biology/Cell Biology or similar field
  • At least 2 years in biotechnology industry
  • Expertise with advanced molecular biology techniques and assay development
  • Experience with gene delivery methods to primary T-cells (e.g., Lentiviral, lipid nanoparticles, AAV)
  • Strong leadership and cross-functional collaboration experience
  • Excellent written and verbal scientific communication
  • Willingness to contribute to a growing early-stage organization and learn new technologies
  • leadership with a track record of achievement
  • cross-functional collaboration
  • clear scientific communication
  • advanced molecular biology techniques
  • assay development and implementation
  • gene delivery to primary T-cells (Lentiviral, lipid nanoparticles, AAV)

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