Overview In this role you will support pharmacokinetic (PK) bioanalysis of large molecules to enable decision-making across discovery and early development. You will independently develop and troubleshoot high-throughput bioanalytical assays and work closely with cross-functional teams to deliver quality data. You will drive data interpretation, assay optimization, and workflow improvements to advance drug discovery. This position offers a chance to impact biologics programs and contribute to Gilead's mission of healthier world outcomes.
Compensation / Benefits- discretionary annual bonus
- discretionary stock-based long-term incentives
- paid time off
- medical, dental, and vision insurance
- life insurance
- benefits package
Responsibilities- Design, develop, and execute bioanalytical assays for large molecules and ADCs
- Perform ligand-binding assays (ELISA, MSD) in various biological matrices to support PK studies
- Independently analyze and interpret experimental data ensuring quality and integrity
- Troubleshoot assay performance issues and implement effective solutions
- Manage PK sample analysis workflows across multiple studies
- Collaborate with DMPK, biology, and project teams
- Prepare presentations and written reports
- Maintain accurate documentation
- Contribute to automation and workflow improvements
- Support broader discovery and screening activities
Key requirements- BS with 5+ years or MS with 3+ years in Pharmaceutical Science, Biochemistry, Biology or related discipline
- 2-3 years industry experience in PK bioanalysis, DMPK, or related field
- Hands-on experience in vivo PK studies for large molecules (e.g., monoclonal antibodies, peptides, biologics)
- Expertise in ligand-binding assays (ELISA, MSD, Gyrolab) including development, optimization, and troubleshooting
- Broad knowledge of PK bioanalytical assays, including ADA
- Ability to analyze and interpret PK data (curve fitting 4PL/5PL, QC evaluation)
- Strong understanding of PK/ADME for biologics (AUC, clearance, half-life, TMDD, nonlinear PK)
- Knowledge of antibody-drug conjugates (ADCs) and their bioanalytical challenges
- Proven ability to design experiments and troubleshoot independently
- Experience with biological matrices (serum, plasma, tissue)
- Ability to manage multiple studies and timelines
- Strong communication and presentation skills
- strong communication
- presentation skills
- cross-functional collaboration
- LC-MS/MS
- in vitro high throughput screening technologies
- HTS formats (96/384/1536-well)
