Overview In this role you will lead targeted proteomics programs to support Kymera's degrader medicines. You will partner with cross-functional teams to translate PD questions into MS assays, drive assay development on state-of-the-art LC-MS systems, and mentor external CRO collaborations. You will present findings to leadership to inform program decisions, enabling translational and clinical-stage advancement.
Compensation / Benefits- base salary (115k-215k)
- annual bonus
- equity participation
- comprehensive benefits
Responsibilities- Define and translate key scientific questions into targeted proteomics experiments
- Develop, optimize, qualify, and transfer MS-based assays (PRM/MRM) for preclinical and clinical studies
- Generate pharmacodynamic profiles across diverse biological matrices
- Oversee CRO proteomics activities including transfer, qualification, execution, and data quality oversight
- Present data-driven findings and strategic recommendations to project teams and senior leadership
- Innovate workflows for sensitive, scalable protein quantification and enabling assays
Key requirements- PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with 2+ years of targeted MS proteomics experience OR BS/MS with 8+ years of relevant experience
- Domain expertise in targeted proteomics and PD-driven drug discovery
- Experience developing multiplexed PRM/MRM assays using DDA/DIA
- Immunoaffinity enrichment methods to improve MS sensitivity
- Experience with nanoLC and Orbitrap MS instrumentation
- Quantitative data analysis using Skyline or similar tools
- Strong cross-functional collaboration and data-driven communication skills
- Experience managing external CRO partnerships and regulatory-style documentation
- Strong written and verbal communication
- Organized and solutions-oriented
- Ability to manage multiple priorities in a fast-paced environment
- Targeted proteomics (PRM/MRM)
- DDA/DIA data acquisition
- Immunoaffinity enrichment
