Overview Senior Scientist at FL129 will help build a first-in-category platform for small molecule drug discovery. You will work closely with both experimental and computational teams to advance DEL-based technology and translate data into actionable insights. As an early employee, you will shape the scientific direction and establish workflows that enable rapid, high-quality results. This role offers substantial ownership and opportunity to contribute to a transformative platform at the edge of biotech.
Compensation / Benefits- healthcare coverage
- annual incentive program
- retirement benefits
- significant ownership as an early employee
- custom-tailored role for growth
- community lunches and social events
Responsibilities- Technology development aligned with core strategic goals and early-stage platform direction
- Design, construction, and QC of DNA-encoded small molecule libraries with validation
- Execute and optimize affinity-based selections against protein targets with controls and enrichment analysis
- Deconvolute and validate screening hits, including off-DNA resynthesis and activity confirmation
- Optimize workflows and implement best practices for platform excellence
- Ensure rapid, accurate data turnaround to drive project milestones
- Translate data into insights and present results to the team
Key requirements- Ph.D. in relevant field with 5+ years of industry or postdoctoral experience
- End-to-end DEL screening experience from design to hit deconvolution
- Hands-on DNA-compatible chemistry expertise (split-and-pool synthesis, building-block validation)
- Experience with encoding/tagging strategies and LC-MS quality control
- Experience with affinity selection formats and controls for DNA-encoded libraries
- Experience with on-DNA and off-DNA hit validation and biochemical/biophysical assays
- Experience managing CROs
- Nice-to-have: cheminformatics, library enumeration, diversity analysis; droplet-based screening/microfluidics; lab automation
- strong collaborative spirit
- excellent organizational and written/verbal communication
- entrepreneurial and proactive
- DNA-encoded library (DEL) design and synthesis
- DNA-compatible chemistry (on-DNA reactions)
- hit deconvolution and validation
