M
Not Specified Permanent

Boston, Massachusetts · USA job

Principal Scientist, Translational Medicine, Neuroscience

Merck Sharp & Dohme (MSD)

Boston, Massachusetts

Job description

Overview

In this role you will drive Translational Medicine and early clinical development for neurological and psychiatric therapeutics. You'll lead cross-functional efforts with discovery, pharmacology, regulatory, and clinical operations to advance programs from preclinical to Proof-of-Concept and beyond. You will shape biomarker strategies and clinical pharmacology plans to support regulatory filings. You will work with global teams to translate scientific insights into patient-focused therapies. This position offers the opportunity to impact neuroscience medicine at scale and collaborate across a diverse scientific network.

Compensation / Benefits
  • annual bonus and long-term incentive
  • comprehensive benefits
  • medical, dental, vision insurance
  • retirement benefits including 401(k)
  • paid holidays, vacation
  • compassionate and sick days
Responsibilities
  • Provide clinical input for target identification/validation and design preclinical/clinical experiments to advance therapeutic targets
  • Collaborate with discovery, pharmacology, toxicology, and other specialists to move programs from preclinical to clinical development
  • Lead early development teams and coordinate with internal/external staff on strategy and execution
  • Lead clinical pharmacology studies across all phases, including formulation changes, DDI studies, and special populations
  • Support regulatory filings with clinical pharmacology data and presentations
  • Develop and execute biomarker studies using blood/tissue sampling, imaging, electrophysiology, wearables, and behavior
  • Assess internal/external partnership opportunities and engage with scientific communities via conferences and publications
  • Work with global research sites and cross-functional functions to support development
Key requirements
  • MD or MD/PhD (or international equivalent) with a track record of biomedical research and publications
  • Clinical medicine experience with residency training completed or anticipated
  • Strong interdisciplinary collaboration and teamwork abilities
  • Willingness to work across therapeutic areas and contribute to translational research
  • Interpersonal skills
  • Strong writing and presentation abilities
  • Team-oriented and collaborative mindset
  • Clinical Development
  • Clinical Research
  • Clinical Trial Planning

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