Overview In this role you will design and execute studies to evaluate targets for RNAi-based therapies, contributing to the nomination process within a cross-functional team. You will generate in vitro and in vivo data to support target validation and data-driven decisions, communicating findings to stakeholders. The position combines hands-on molecular biology and cell-based assay work with in vivo rodent studies, enabling you to shape the early discovery pipeline. You'll work in a collaborative, fast-paced environment focused on innovative therapeutics with a strong emphasis on data integrity and impact.
Compensation / Benefits- medical, dental, and vision coverage
- life and disability insurance
- 401(k) with generous match
- paid time off and wellness days
- two company-wide recharge breaks
- family resources and leave
Responsibilities- Design, develop, and execute studies to evaluate targets for nomination into RNAi discovery programs
- Collaborate with cross-functional teams under project leads to meet goals
- Execute molecular biology assays (RNA/DNA/protein extraction, qPCR, ELISA, WB, etc.)
- Design, develop, and execute in vitro cell-based assays (cell lines, spheroids, organoids, iPSC culture; 96/384-well formats) to probe target pathways and drug activity
- Perform in vivo procedures in rodents and administer therapeutics using established methods
- Analyze, interpret, and document data with strong attention to detail and data integrity
- Present results to stakeholders within teams and across the organization
Key requirements- Bachelor degree in a scientific discipline with 5+ years of relevant lab experience or Master with 3+ years of relevant lab experience
- Hands-on experience with standard molecular biology techniques
- Hands-on experience with mammalian cell culture and cell-based assays
- Hands-on experience with 96-well and 384-well plate-based assays
- Basic rodent in vivo skills and tissue processing/primary cell culture preferred
- Ability to troubleshoot assays independently and design experiments
- Strong understanding of experimental design and data interpretation
- Flexibility to take on new tasks and work under tight deadlines
- Experience collaborating in a cross-functional team
- collaborative mindset
- strong communication
- attention to detail
- molecular biology techniques
- mammalian cell culture
- in vitro cell-based assays
