Overview In this wet-lab role, you design, execute, and interpret in vitro studies that support muscle biology and neuromuscular drug discovery. You will work within the Muscle Biology team, collaborating with cross-functional scientists to generate data that informs target validation and functional genomics. The position is based in Durham, NC or Cambridge, MA, with in-person lab work five days a week. You will develop and apply assays to identify targets, evaluate biology in screening models, and contribute scientific insights across projects. This is an opportunity to shape translational work in a patient-focused, science-driven company.
Responsibilities- Design and execute assays/screens to identify and validate novel targets in screening models
- Develop novel in vitro assays for functional genomics and drug development
- Provide scientific insight on Muscle Biology projects in consultation with cross-functional stakeholders
- Develop hypotheses, drive scientific learnings, and contribute to neuromuscular project progress
Key requirements- BS with 5-10 years (Scientist II) OR MS/PhD with relevant experience; or BS/MS with 12+ years or PhD with 5-10 years (Senior Scientist)
- 1+ years experience with in vitro models of muscle cell biology and/or neuromuscular diseases
- 1+ years experience applying cellular and biochemical techniques for target identification, validation, and mechanism evaluation
- 1+ years experience in molecular biology approaches and advanced cell biology techniques (flow cytometry, gene/protein analysis, PCR, cloning, lentiviral library prep)
- Excellent communicator, able to work across disciplines, independently manage priorities, and thrive in a multidisciplinary environment
- excellent communication
- independence
- cross-functional collaboration
- in vitro models of muscle cell biology
- cellular and biochemical techniques for target identification and mechanism evaluation
- molecular biology approaches (PCR, cloning)
