Overview In this role you will provide scientific leadership for DEL selection campaigns within small-molecule drug discovery. You will design and execute DEL screening strategies, interpret sequencing data, and prioritize hits while leading cross-functional efforts to advance hits through hit-to-lead. Expect close collaboration across chemistry, biology, biophysics, structural biology, and computational chemistry to drive impactful decisions. You will shape DEL workflows and mentor scientists in a fast-paced, innovative environment.
Compensation / Benefits- base salary and incentives
- medical, dental, vision insurance
- 401(k) plan with company match
- tuition reimbursement
- paid volunteer time off
- well-being benefits
Responsibilities- Design and implement DEL selection strategies aligned with discovery objectives
- Plan and execute DEL screening and affinity-capture campaigns across diverse target proteins
- Analyze DEL sequencing/enrichment data to identify meaningful hit series
- Establish data-quality and hit-prioritization criteria (enrichment, potency, selectivity)
- Lead hit identification, validation, and off-DNA resynthesis with orthogonal assays
- Scale screening infrastructure, optimize reagent validation, and integrate NGS sample prep
- Coordinate cross-functional teams to advance DEL-derived hits to hit-to-lead
- Collaborate with chemistry, biology, biophysics, structural biology, computational chemistry, DMPK, and leadership
- Support design of follow-up libraries and focused DEL campaigns
- Provide interpretation of DEL results and actionable project recommendations
- Develop and maintain best practices, workflows, and SOPs for DEL selection/data analysis
- Manage collaborations with vendors/partners
- Present strategy, results, and recommendations to teams and senior leadership
- Mentor scientists and foster a collaborative, rigorous research environment
Key requirements- PhD with 6+ years, MS with 12+ years, or BS with 14+ years in a relevant field
- Hands-on DEL selection design, screening workflows, and interpretation
- Excellent scientific communication
- Cross-functional collaboration
- Project leadership
- DEL selection design and screening workflows
- DEL data analysis and sequencing data interpretation
- Hit triage and prioritization (enrichment, potency, selectivity)
