Overview Calico seeks an experienced Process Chemist to design, optimize and scale synthetic processes for small-molecule intermediates and APIs. You will work in a lab-focused, collaborative environment to translate laboratory findings into robust manufacturing processes, supporting cross-functional teams and technology transfer. The role offers the chance to impact drug substance development in a mission-driven, aging-science context. You will drive efficiency, safety, and impurity control across scalable workflows.
Compensation / Benefits- base salary range $198,000 - $241,000
- two annual cash bonuses
Responsibilities- Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
- Improve yields, selectivity, throughput, and impurity control through laboratory experiments
- Analyze reactions with HPLC, GC, LC-MS and related techniques
- Identify and synthesize impurities
- Mitigate process risks related to safety, scalability, and robustness
- Collaborate with analytical chemistry, formulations, and quality assurance
- Prepare data-driven reports and present results to project teams
- Support technology transfer to contract manufacturers, including review of master batch records
- Maintain accurate lab documentation and ensure safety/compliance
Key requirements- PhD in Organic Chemistry or related field with 8+ years in process chemistry
- Strong expertise in synthetic organic chemistry and reaction mechanisms
- Proven success in developing scalable synthetic processes
- Proficiency with standard analytical instruments and data interpretation
- Excellent problem-solving, organization, and communication skills
- Ability to work independently and in a team
- Familiarity with cGMP and ICH guidelines
- Strong attention to detail and commitment to high-quality experimentation
- Ability to manage multiple projects and shifting priorities
- Proactive, collaborative mindset and enthusiasm for process improvement
- Willingness to work onsite 5 days a week
- problem-solving
- organization
- clear communication
- organic synthesis
- reaction mechanism fundamentals
- HPLC
