Overview In this role you will lead protein reagent generation and assay development to support challenging drug discovery campaigns, including TPD programs. You will guide a small team and provide scientific leadership across discovery-from hit identification to optimization. You'll champion protein production and mechanistic characterization to advance small-molecule therapeutics, collaborating with cross-functional teams to shape programs and strategy. This is a mission-driven opportunity to impact patients through cutting-edge biochemistry and protein science.
Compensation / Benefits- Retirement and Savings Plan with company contributions
- group medical, dental and vision coverage
- life and disability insurance
- flexible spending accounts
- discretionary annual bonus
- stock-based long-term incentives
Responsibilities- Lead protein expression, purification, and characterization strategies for challenging proteins
- Develop and implement biochemical and biophysical assays to support hit identification, validation, optimization, and mechanism-of-action studies
- Serve as a scientific partner to cross-functional discovery teams
- Lead and develop a small team of scientists, providing direction and mentorship
- Contribute to scientific strategy and communicate findings to project teams and leadership
Key requirements- PhD in Biochemistry, Chemical Biology, Structural Biology, Protein Engineering with 2 years of industry drug discovery experience OR Master's with 5 years OR Bachelor's with 7 years
- Proven expertise in protein purification and biochemical assay development for challenging targets
- Experience in protein expression across mammalian, insect, and microbial systems
- Strong background in biochemical and biophysical approaches to study target engagement, protein-protein interactions, and small molecule mechanism-of-action
- Hands-on experience with TR-FRET/HTRF, fluorescence polarization, AlphaLISA, and BLI/SPR
- Familiarity with targeted protein degradation (TPD) and induced proximity modalities
- Track record of collaboration across cross-functional discovery teams
- Ability to manage priorities across multiple discovery programs
- Leadership and mentorship capabilities
- collaboration
- scientific leadership
- mentorship
- protein purification
- protein expression (mammalian, insect, microbial)
- biochemical assay development
